No Way Out

No Easy Way Out (Or in)

In retrospect, when Jardetzky (1966) published a " simple allosteric model for membrane pumps, " he initiated a conceptual movement away from the (then still) prevailing anthropomorphic view of transporters and pumps as " carriers " in the literal sense, membrane-bound entities that somehow made their way across the membrane, loaded with cargo. The idea of an " alternating access " model (as it...

The hepatopulmonary syndrome: NO way out?

"How diseases of the liver affect lung function?" is one of those puzzling questions that can turn obsessive for those who want to understand how two seemingly distinctive organs can interact and eventually lead to severe disorders [1, 2]. The most common respiratory consequence of liver disease is hypoxaemia, which is often mild to moderate [3]. Seldom severe hypoxaemia occurs when the arteria...

Drug resistant hypertension – no simple way out.

Hypertension poses growing challenge for health policy-makers and doctors worldwide. Recently published results of Symplicity-III trial (HTN-3), the first blinded, randomized, multicenter study on the efficacy of renal denervation for the treatment of resistant hypertension did not show a significant reduction of BP in patients with resistant hypertension 6 months after renal-artery denervation...

No Way out 1 the Timeless Trap

No Easy Way Out ( or In )